Protein Labeling Reagents
Biotium HCG-beta(HCGb/54), CF568 conjugate, 0.1mg/mL
This MAb reacts with a protein of 22 kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.Primary antibodies are available purified, or with a selection of fluoresce
Biotium CD35 / CR1(E11), CF568 conjugate, 0.1mg/mL
Recognizes a protein of 210-220 kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21 /CD35 /CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S
Biotium CD56 / NCAM(123C3.D5), CF640R conjugate, 0.1mg/mL
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135 kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are
Biotium CD10(CB-CALLA), CF568 conjugate, 0.1mg/mL
CD10 (also known as Common Acute Lymphocytic Leukemia Antigen (CALLA)) is a type II transmembrane protein. It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium CD33(WM53), CF568 conjugate, 0.1mg/mL
Recognizes a 67 kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. No
Medchemexpress LLC Sulfo-NHS-LC-biotin sodium | 191671-46-2 | MFCD00078534 | 98.0% | 556.59 | C20H29N4NaO9S2 | 10 MG
Sulfo-NHS-LC-Biotin sodium is a water-soluble, amine-reactive sulfo-NHS ester of biotin with a long-chain spacer (LC) that enables efficient labeling of primary amines on proteins and other biomolecules. It is formulated as the sodium salt to improve aqueous solubility and is suited for selective cell-surface biotinylation, detection, and affinity capture applications.
- Amine-reactive sulfo-NHS ester for efficient biotinylation.
- Long-chain spacer reduces steric hindrance and preserves biomolecule function.
- Water-soluble sodium salt suitable for aqueous labeling of surface proteins.
- Limited membrane permeability for selective cell-surface labeling.
- High purity and well-characterized for reproducible results.
- Soluble in DMSO (approx. 175 mg/mL); store sealed and away from moisture.
![Medchemexpress LLC 4-Imidazolidinehexanamide, N-[2-[(2-iodoacetyl)amino]ethyl]-5-methyl-2-oxo-, (4R,5S)- | 2924824-04-2 | MFCD34641797 | 99.5% | 424.28 | C14H25IN4O3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000287218.png-250.jpg)
Medchemexpress LLC 4-Imidazolidinehexanamide, N-[2-[(2-iodoacetyl)amino]ethyl]-5-methyl-2-oxo-, (4R,5S)- | 2924824-04-2 | MFCD34641797 | 99.5% | 424.28 | C14H25IN4O3 | 10 MG
Desthiobiotin-iodoacetamide is an iodoacetamide-derived desthiobiotin reagent used in bioconjugation and chemoproteomics. It selectively reacts with cysteine residues to label and enrich proteins, and can be employed in antibody-drug conjugate (ADC) linker chemistry or as a probe in protein labeling workflows. The compound is supplied as a solid powder and is intended for research use only.
- Reacts with cysteine residues for selective labeling.
- Enables ADC linker formation for conjugation workflows.
- Facilitates affinity enrichment and proteomic profiling.
- High reported purity for consistent experimental performance.
- Stable solid form with recommended cold storage for longevity.
